Pilot Operations in Slough, UK

Combining Scale-Up and Quality By Design

Following the successful development of the Potelligent® CHOK1SV® cell line by scientists at KHK and Lonza, the power of a Potelligent® mAb is available with the industry standard GS Gene Expression System®.

The Potelligent® CHOK1SV® cell line has similar properties to the parental CHOK1SV® cell line and has been shown to produce entirely fucose-free antibodies with the expected ADCC enhancement.  Potelligent® CHOK1SV® has undergone extensive trials in Lonza’s processes with a range of antibodies. A full range of protocols is available for the creation of highly productive cell lines.

Figures 1 and 2:  Growth and productivity characteristics of CHOK1SV® and Potelligent® CHOK1SV® derived cell lines in 10L fed-batch bioreactors (cell lines producing the same antibody).