Cocoon™ System

The Cocoon™ system is based on an automated GMP-in-a-box concept for patient-scale cell therapy manufacturing. The goal is to provide a scalable, cost-efficient solution to address cell therapy manufacturing bottlenecks. 

Lonza’s Cocoon™ instrument is a closed, automated, highly flexible cell therapy manufacturing platform. Traditionally, users compromise flexibility when migrating to a closed, automated system. The Cocoon™ platform bridges this gap via the Cocoon’s™ single-use, highly customizable cassette. Lonza has significant experience advancing programs from pre-clinical through commercial-scale manufacturing and the Cocoon™ system adds to these capabilities. Whether searching for a manufacturing partner, independently running development work, or somewhere in between, Lonza and the Cocoon™ platform can create a project plan to fit your process.

Cocoon™ instrument

Lonza’s Cocoon™ instrument provides:

  • End to end manufacturing of cell therapy products with key unit operations, including isolation, activation, transduction, expansion and harvest
  • Fully enclosed manufacturing with minimal touchpoints
  • Custom cassettes and custom programming to ensure maximum flexibility with your process development
  • Monitoring and control of temperature and gases, pH and DO
  • Information logging and control with electronic batch records for full product traceability
  • Hands-off cultivations through an integrated 4°C cold chamber that allows for preloading of process reagents
  • Flexibility for pre-clinical scale, with option to move to restricted unit operation for scale up to commercial manufacturing
  • Our support and consulting services for process development, regulatory affairs, and quality assurance

For more information, fill out a contact form.

*The Cocoon™ platform is currently in final testing with select partners and not yet available for all cell and gene therapy customers.